LymphedemaV1, Main, Exploration, bibRecord, 002E41

A Tale of Two Models: Mouse and Zebrafish as Complementary Models for Lymphatic Studies

Identifieur interne : 002E41 ( Main/Exploration ); précédent : 002E40; suivant : 002E42

A Tale of Two Models: Mouse and Zebrafish as Complementary Models for Lymphatic Studies

Auteurs : Jun-Dae Kim ; Suk-Won Jin

Source :

Molecules and Cells [ 1016-8478 ] ; 2014.

RBID : PMC:4132301

Descripteurs français

KwdFr :
- Animaux, Cellules endothéliales (physiologie), Danio zébré, Facteur de croissance endothéliale vasculaire de type A (métabolisme), Humains, Lymphoedème (), Lymphoedème (physiopathologie), Modèles animaux, Métabolisme des lipides, Souris, Thérapie moléculaire ciblée, Transduction du signal, Vaisseaux lymphatiques (physiologie).
MESH :
- métabolisme : Facteur de croissance endothéliale vasculaire de type A.
- physiologie : Cellules endothéliales, Vaisseaux lymphatiques.
- physiopathologie : Lymphoedème.
- Animaux, Danio zébré, Humains, Lymphoedème, Modèles animaux, Métabolisme des lipides, Souris, Thérapie moléculaire ciblée, Transduction du signal.

English descriptors

KwdEn :
- Animals, Endothelial Cells (physiology), Humans, Lipid Metabolism, Lymphatic Vessels (physiology), Lymphedema (physiopathology), Lymphedema (therapy), Mice, Models, Animal, Molecular Targeted Therapy, Signal Transduction, Vascular Endothelial Growth Factor A (metabolism), Zebrafish.
MESH :
- chemical , metabolism : Vascular Endothelial Growth Factor A.
- physiology : Endothelial Cells, Lymphatic Vessels.
- physiopathology : Lymphedema.
- therapy : Lymphedema.
- Animals, Humans, Lipid Metabolism, Mice, Models, Animal, Molecular Targeted Therapy, Signal Transduction, Zebrafish.

Abstract

Lymphatic vessels provide essential roles in maintaining fluid homeostasis and lipid absorption. Dysfunctions of the lymphatic vessels lead to debilitating pathological conditions, collectively known as lymphedema. In addition, lymphatic vessels are a critical moderator for the onset and progression of diverse human diseases including metastatic cancer and obesity. Despite their clinical importance, there is no currently effective pharmacological therapy to regulate functions of lymphatic vessels. Recent efforts to manipulate the Vascular Endothelial Growth Factor-C (VEGFC) pathway, which is arguably the most important signaling pathway regulating lymphatic endothelial cells, to alleviate lymphedema yielded largely mixed results, necessitating identification of new targetable signaling pathways for therapeutic intervention for lymphedema. Zebrafish, a relatively new model system to investigate lymphatic biology, appears to be an ideal model to identify novel therapeutic targets for lymphatic biology. In this review, we will provide an overview of our current understanding of the lymphatic vessels in vertebrates, and discuss zebrafish as a promising in vivo model to study lymphatic vessels.

Url:

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4132301

DOI: 10.14348/molcells.2014.0108
PubMed: 24854860
PubMed Central: 4132301

Affiliations:

Le document en format XML

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<term>Lymphedema (physiopathology)</term>
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<term>Lymphoedème ()</term>
<term>Lymphoedème (physiopathologie)</term>
<term>Modèles animaux</term>
<term>Métabolisme des lipides</term>
<term>Souris</term>
<term>Thérapie moléculaire ciblée</term>
<term>Transduction du signal</term>
<term>Vaisseaux lymphatiques (physiologie)</term>
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<keywords scheme="MESH" qualifier="métabolisme" xml:lang="fr"><term>Facteur de croissance endothéliale vasculaire de type A</term>
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<term>Lymphoedème</term>
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<term>Métabolisme des lipides</term>
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<front><div type="abstract" xml:lang="en"><p>Lymphatic vessels provide essential roles in maintaining fluid homeostasis and lipid absorption. Dysfunctions of the lymphatic vessels lead to debilitating pathological conditions, collectively known as lymphedema. In addition, lymphatic vessels are a critical moderator for the onset and progression of diverse human diseases including metastatic cancer and obesity. Despite their clinical importance, there is no currently effective pharmacological therapy to regulate functions of lymphatic vessels. Recent efforts to manipulate the Vascular Endothelial Growth Factor-C (VEGFC) pathway, which is arguably the most important signaling pathway regulating lymphatic endothelial cells, to alleviate lymphedema yielded largely mixed results, necessitating identification of new targetable signaling pathways for therapeutic intervention for lymphedema. Zebrafish, a relatively new model system to investigate lymphatic biology, appears to be an ideal model to identify novel therapeutic targets for lymphatic biology. In this review, we will provide an overview of our current understanding of the lymphatic vessels in vertebrates, and discuss zebrafish as a promising in vivo model to study lymphatic vessels.</p>
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Serveur d'exploration sur le lymphœdème

A Tale of Two Models: Mouse and Zebrafish as Complementary Models for Lymphatic Studies

A Tale of Two Models: Mouse and Zebrafish as Complementary Models for Lymphatic Studies

Source :

Descripteurs français

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri

Pour générer des pages wiki

	Serveur d'exploration sur le lymphœdème
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